xrayspx mentioned the NFL talking about 2K1, 2K2 ... this perhaps sounds a little contrived, but it's not that bad an idea.
With Microsoft still being extremely widely influential (I won't tempt /. trolls further :-) and pushing the abbreviation win2k for Windows 2000, I think there is certainly scope at the beginning of this decade for the phrase "2k" to translate to "2000" pretty effortlessly.
As computing technology has spread throughout the population, so the -M and -K suffixes have been more prevalent. I'd still defy "most" PC users to be quite sure they know what an -M or a -K actually is, but I think they recognise K as a multiplier.
Of course, by the end of the 2Ks virtually no-one will be using K in computing terms, as pretty much no-one is using bits or bytes these days (yes, I do, and always will - that's because of the segment of the industry I'm in, but the other 80%?)
So, I think that the 2Ks may be a strong contender :-)
Quick wafting zephyrs vex bold Jim