Of ever getting off this mud-ball seems to now rest entirely in the hands of amateur rocket enthusiasts. (Isn't that always the way, though? :)
Russia can't, in any real sense, afford to launch a rocket, let alone build one. The ESA has never been interested in anything beyond commercial rocketry. NASA were the ONLY organization capable of launching a rocket on scientific or exploratory missions.
However, the budget cuts pretty much guarantee that NASA is effectively dead. This means that research into efficient drives (such as the ion drive) would be meaningless for them. If they built them, they'd never be able to launch them.
Commercially, there's more profit to be made in pager systems and mobile phones than there is in space exploration. And most of those systems can be more effectively be moved to high-altitude balloons than to satellites. (Balloons are cheaper to build, cheaper to launch, and require less power to transmit to/from.)
The ISS is effectively also dead. Without launchers, you can't get the pieces up there, and with only 6 shuttle launches a year, now, they can't do their regular missions =AND= ISS work.
That means that we've no research space station. Which we need, if we want to do any meaningful work in space. Most money in zero-g is to be made in ultra-pure pharmacuticals, but you can do that in a remote vehicle designed to orbit a few times and then land. You don't need people involved.
So, if you want someone to land on the moon, in your lifetime, you've a better chance with the amateurs than the professionals, cos the professionals are finished.
(Those who like reading over ancient posts might remember that I've predicted this before, a few times, over on Slashdot. Partly in humor, but partly seriously. Looks like the serious side won. :()